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It directly binds to Nrf2 and promotes GPX4 transcription, which in turn inhibits ferroptosis after IRI and ameliorates brain damage ( ICA compounds significantly enhanced GSH-Ps, SOD activities and alleviated oxidative stress injury in mouse brain tissue after gastric administration of ICA compounds in APP/PS1 double transgenic mice

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One randomized placebo-controlled trial that assessed the effect of oral lipoic acid supplementation in 58 patients diagnosed with metabolic syndrome, a condition characterized by abnormal glucose and lipid metabolism, showed that flow-mediated vasodilation improved by 44% with 300 mg/day of lipoic acid for four weeks (66)

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Collaborating with healthcare professionals ensures a tailored approach to supplementation, optimizing individual health needs and enhancing treatment outcomes