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Effects of dietary reduced glutathione on growth and antioxidative capability of Japanese flounder, Paralichthys olivaceus

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The oxyanion hole in the UCH DUB family consist of amide functional groups, either on a glutamine side-chain or a backbone amides, where the nitrogen atoms form hydrogen bonds with the substrate carbonyl oxygen of the scissile peptide bond to stabilize the transition state thereby facilitating the catalytic turnover to cleave ubiquitin

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Similarly, it is also recognized that in some cases, cleavage of the signal sequence from a secreted protein is not entirely uniform, resulting in more than one secreted species