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Nat Commun 6, 8289

Histopathological hallmarks include hepatic swelling, vacuolar degeneration, and necrosis, while clinical markers feature elevated serum transaminases (ALT, AST) and bilirubin, alongside reduced albumin, indicating compromised liver function ( TNF- , IL-1 , IL-6 , and IL-8 , alongside anti-inflammatory mediators like IL-10 ( The zebrafish model has emerged as a powerful system for deconstructing this complexity (Table 3), owing to its high evolutionary conservation in liver morphology and function, including a well-characterized suite of CYP450 enzymes and a drug metabolism system that parallels human pathways ( in vivo DILI studies in larvae

Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG

This method makes it possible to identify subclinical inflammation early on and offers repeatable data for monitoring treatment response or progression

del Rio, B., Seegers, J

[DOI] [PubMed] [Google Scholar] 44