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Collectively, these studies underscore the implications of the wide variation in DPP1 expression and its far-reaching downstream effects, supporting future investigations of DPP1 not only as a biomarker but also as a therapeutic target to combat cancer progression

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Lipid rafts facilitate this process by pooling activated receptors and protecting the signaling complex from non-active enzymes, such as membrane phosphatases, that might otherwise disrupt the signaling cascade

Andre, T, Lonardi, S, Wong, KM, Lenz, HJ, Gelsomino, F, Aglietta, M, Morse, MA, Van Cutsem, E, Mcdermott, R, Hill, AG, Sawyer, MB, Hendlisz, A, Neyns, B, Abdullaev, S, Memaj, A, Lei, M, Dixon, M, Kopetz, S , Overman, MJ