nebulized glutathione for aspergillus fumigatus: Principles of Pathogenesis and Host Defense The Toxic Mechanism of Gliotoxins

ACS Nano 13 , 1235712371 (2019)

135 Pericytes may also reduce contractility through stimulation with a macrophage migration inhibitory factor secreted by endothelial cells, enhancing neutrophil extravasation

Anti-inflammatory treatments, such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, can help reduce leukocyte activation and ROS production

The mixtures were sampled every hour for eight hours and analyzed by LCMS

Secondary outcomes were categorised into: (i) blood or CSF biochemical redox markers such as GSH, GSSG, GSH/GSSG ratio, cysteine and 4-hydroxynonenal (4-HNE), (ii) brain biochemical imaging markers such as H-MRS-derived brain GSH, and (iii) imaging-based functional outcomes, inlcuding DAT binding assessed by DaTscan SPECT, which were interpreted as supportive mechanistic evidence rather than primary indicators of clinical efficacy

[vi] Dose Acceleration Next, the dose range and dose acceleration schedule should be determined