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Dermatol Ther 34:e14915 Mlejnek P (2022) Direct interaction between N-acetylcysteine and cytotoxic electrophilean overlooked in vitro mechanism of protection

Pyruvate kinase (PK) is the last key enzyme that catalyzes the glycolysis process, converting phosphoenolpyruvate to pyruvate

To test this hypothesis, German Holstein cows were assigned to a control group (CON, n = 26) and an L-carnitine supplemented group (CAR, n = 27, rumen-protected L-carnitine product: 125 g/cow/d, corresponded to total L-carnitine intake: 25 g/cow/d, supplied with concentrate) and received an intravenous bolus injection of lipopolysaccharides (LPS, 0.5 g/kg body weight, E