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Remarkably, SA--gal is one of the widely used markers for identifying senescence in vitro and in vivo, which is linked to increased level of lysosomes 39,40,41

officinale could inhibit inflammatory mediators of COX-2 with IC 50 values of 32, 7.5, and 17.5 M, respectively, but there is no inhibitory activity reported in COX-1

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Increased inflammation can lead to increased ROS production and vice versa

By delving into the regulatory processes of ferroptosissuch as iron ion metabolism, ROS generation, and the equilibrium of antioxidant defenseswe can gain clearer insights into its involvement in eye diseases