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doi:10.3390/molecules191119066 Seiwerth S, Rucman R, Turkovic B, et al

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For Lr GUS and Fp GUS crystallisation, an additional 36 amino acids and 33 amino acids were added to the C-termini of the Lr GUS and Fp GUS proteins, respectively, using the C-term primers (Table S2)

They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)