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Methods: Polymicrobial sepsis was induced in Control (vehicle) mice and mice treated with DAPT, a -secretase inhibitor that blocks Notch signaling activation

Elevated GPX4 also attenuates NF-B activation (208) and suppresses fibroblast IL-6 release (209), mitigating fibrosis

There was not enough evidence to explore the association between Met and GSH when used as adjunctive treatment, which needs to be evaluated in future studies