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In vivo L2-Cmu validation studies were performed in 45-mo-old C57BL/6J male mice (Jackson Labs, Bar Harbor, ME)

To validate our findings, we used atp-3 RNAi, a positive control, which is known to cause mitochondrial fragmentation due to ATP synthase dysfunction 85,86

Schmitt C, Hofmann C, Riek M, Patel A, Zwanziger E

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Simple Combinations of Lineage-Determining Transcription Factors Prime Cis-Regulatory Elements Required for Macrophage and B Cell Identities

Possible reasons may include the difficulty in distinguishing the effects of endogenous versus exogenous lactate, as well as challenges in translating findings into broad clinical applications