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Disclosures: Sudeep Tanwar: Nothing to Disclose, Walter Gregory: Nothing to Disclose, The ELUCIDATE Investigators: Nothing to Disclose, Peter Selby: Nothing to Disclose, William Rosenberg: Nothing to Disclose 2039 SERUM THROMBOSPONDIN 2 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 PREDICT ADVANCED LIVER FIBROSIS IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY Rambabu Surabattula 1 Valentina Strohmeier 2 Anna-Maria Globig 2 Sudha Myneni 1 Maximilian Heeg 2 Gerhard Kindle 2 Sigune Goldacker 2 Caroline von Spee-Mayer 2 Michele Proietti 3 Birke Bausch 2 Dominik Bettinger 2 Michael Schulthei 2 Robert Thimme 2 Klaus Warnatz 2 Detlef Schuppan 1 , 1 University Medical Center Mainz, 2 University Medical Center Freiburg, 3 Hannover Medical School Background: Timely detection of segmental fibrosis and portal hypertension as a manifestation in a significant subgroup of patients with CVID (Common Variable Immunodeficiency) is a challenge, as it is usually not associated with classic liver cirrhosis

Research indicates that middle-aged women exhibit greater susceptibility compared to men and children

Ann Clin Psychiatry (2009) 21:14861

Further, cells in the absence of WRN have defects in DNA double-strand breaks, especially those bound with DNA replication fork arrest

1 E11VEN Glutathione 1499 1 E11VEN Glutathione + 1 E11VEN Glowberry 1799 2 E11VEN Glutathione + FREE 1 E11VEN Glowberry 2998 E11VEN Opitac Glutathione Promos

This connection has been previously described alongside functional deficits in the 6-OHDA model of PD (Tuppy et al., 2015