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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

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In both cellular and animal models, Epitalon shows promise in enhancing neuroplasticity, maintaining cholinergic tone, and reducing oxidative DNA damage, all hallmarks of both healthy brain aging and resistance to cognitive decline