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For clarity, qualitative descriptors of evidence strength (such as shown in Figures 1, 6) used in this review are defined as follows and are intended to aid interpretation across heterogeneous study designs rather than imply formal clinical grading: Strong in vitro evidence: reproducible effects shown in 2 independent studies using quantitative, standardized assays (e.g., MIC, timekill, biofilm or quorum-sensing assays) across multiple microbial strains or species