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J Am Dent Assoc 147(4):295-305

No warranty, express or implied, is made regarding the accuracy, completeness, or currentness of information presented

18 FrankoDLGattarioKHFrisenASmolakLThompsonJK

Environmental toxin exposure pesticides, heavy metals, air pollution, certain medications, and other xenobiotic exposures all increase the rate at which glutathione is consumed by Phase II detoxification

This leads to a dysfunction in ATP-dependent ion transport processes, culminating in increased intracellular and mitochondrial calcium levels (calcium overload), cellular swelling, rupture, and cell death via various pathways including necrosis, apoptosis, and autophagy