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The stepwise transformations of formaldehyde within these pathways are well understood ( Figure 2 )

These Tbk1 fl/fl :CD11c-Cre mice have an increased frequency of activated IFN--producing CD4 + and CD8 + T cells, while Tregs remain comparable to TBK1-sufficient mice

A high affinity, low capacity and a low affinity, high capacity process

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Experimental models utilizing TGF- have successfully mimicked these pathogenic characteristics, thus demonstrating its essential role in promoting airway remodeling associated with EMT (Figure 1) [80]

Longterm systemic data are limited, so professional dosing and monitoring are important