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This downregulation is followed by a decrease in nonmethylated cytosine levels and an increase in DNMT1 and DNMT3A methyltransferases

Wertz IE, ORourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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Moreover, 5-hmC is also enriched within gene bodies and at intronexon boundaries of synaptic plasticity-related genes [42]