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The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions, such as pH adjusting and buffering agents, tonicity adjusting agents, wetting agents, and the like, for example sodium acetate, sodium lactate, sodium chloride, potassium chloride, calcium chloride, sorbitan monolaurate, triethanolamine oleate,.etc

In AD brain tissue, a decrease in SAM led to DNA hypomethylation (Morrison et al., 1996), which in turn upregulated genes associated with the formation of neuritic plaques such as CACNA1H , PSEN1 , and PEN2 (Zhao et al., 2017

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