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doi: 10.1016/j.jpeds.2021.01.008 40 GasparoniACiardelliLAvanziniACastellazziAMCariniRRondiniGet al

Treatment of hepatocellular carcinoma cells with a Cu(II) complex containing a triphenyl-phosphine (TPP) ligand, [Cu(ttpy-tpp)Br 2 ]Br, induced significant ROS generation, which resulted in disrupted mitochondrial membrane potential, the aggregation of Bax in mitochondria, and the release of cytochrome c (Shao et al

EXAMPLE 5 COMBINATION OF GSH AND CHLORPROMAZINE A combination pharmaceutical is provided to ameliorate the detrimental effects of chlorpromazine, a phenothiazine drug that causes side effects, including tardive dyskinesia, possibly relating to excess free radical reactions