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This is why so many creatine supplements come in drink mixes rather than as capsules

Pyridoxine helps lower elevated homocysteine, a risk factor for cardiovascular disease, thereby supporting heart health

doi: 10.1016/j.jand.2022.06.156

It has not gone through the approval process that establishes safety and efficacy for a defined clinical use, and it should be understood as investigational and research-only