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Deglutathionylation of Cys sulfenic acid forms a disulfide bridge that can transmit the signal of oxidative stress and influence the transcriptional factors (Fig

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Their first patient ingested about 5 g of potassium cyanide and became comatose with a weak pulse and respiratory distress, but recovered after being given 1500 mg of sodium nitrite and 18 g of sodium thiosulfate

Researchers have been studying the commonalities between all polyQ SCAs (SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17) to uncover similar mechanisms of pathophysiology that are targetable as treatments [31, 261, 262]