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Metabolomics biomarkers: a strategy toward therapeutics improvement in ALS

For AuNC clearance study, the catalytically optimised AuNCs (10 M, 200 L) or DPBS (200 L) were injected i.p

cGAMP binds to and activates the endoplasmic reticulum transmembrane receptor STING, finally resulting in the production and release of type I interferons (IFN), which are potent anti-viral and anti-cancer cytokines (136)

5-(and -6)-Carboxy-2,7-dihydrochlorofluorescein-diacetat (5/6-Carboxy-DCF) is a derivative of H 2 DCF-DA that contains two additional carboxyl groups that enhance its hydrophilicity and therefore strongly increase its retention in the cytosol