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Ann Rheum Dis 69:12271231 Mustonen A-M, Sisnen L, Karttunen L, Julkunen P, Esrafilian A, Reijonen J, Mki J, Krger H, Arokoski J, Nieminen P (2025) Plasma amino acids reflect cartilage loss, osteoarthritis pain, functional disability, and mental health in a longitudinal study with total knee replacement, manuscript in revision

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A 40-year-old female with history of kidney transplant on immunosuppressants was started on antibiotics for pneumonia

We hypothesize that these metabolic disturbances are linked to inflammation in a bidirectional manner with disturbed gut microbiota as a potential contributing factor

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It is present in 90% of children, and doctors recommend treatment through diet improvement, medicine, and hydration