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This effect of Rac1 was initially demonstrated in Drosophila (Shuai et al., 2010) where controlled expression of dominant negative and constitutively active Rac1 mutants in the MBs using the Gal/UAS binary system delayed and facilitated aversive olfactory memory decay, respectively, without affecting memory acquisition (Shuai et al., 2010)

10.1126/science.286.5448.2358 [DOI] [PubMed] [Google Scholar] Rosen E

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Specifically, the study revealed a significant negative association between mtDNAcn and sperm concentration ( b = 0.109, P = 0.002) as well as total sperm count ( b = 0.128, P = 0.001) (Fig

Together, our findings reinforce the longer-term safety profile and tolerability of this class of therapy and encourage further development in patients with end-stage liver disease