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The analysis of data retrieved from four cancer databases (COSMIC, cBioPortal, ICGC, and TCGA) reveals significantly higher mutation rates for KRAS than for HRAS and NRAS (160)

For example, approximately 27% of SCLC has a SOX2 amplification ( Prominent phenotypic features of small cell lung cancer also lack drug therapy alternatives

It was hypothesised that due to an excessive dampening of the of the immune response, there was an increase opportunity for secondary infections (91)

NPY1R-targeted peptide-mediated delivery of a dual PPAR/ agonist to adipocytes enhances adipogenesis and prevents diabetes progression

Nitric Oxide mediates apoptosis via induction of peroxynitrite and Fas/Fas-ligand interactions in EAU [28]

10.1016/j.mam.2018.03.002 Mol Aspects Med