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Adverse effects have included stomatitis, nausea, vomiting, fever, rhinorrhea, drowsiness, clamminess, chest tightness, and bronchoconstriction

Patients with PCOS may experience: reproductive abnormalities inflammation correlated with insulin resistance irregular or absent menstrual periods excess androgens (male hormones such as testosterone) polycystic ovaries resulting from the hormonal imbalances hirsutism (male-patterned hair growth) acne alopecia (thinning or loss of scalp hair) Additionally, both reproductive-age and older women with PCOS have an increased risk for conditions such as: impaired glucose tolerance type 2 diabetes mellitus elevated cholesterol or lipids increased abdominal adiposity obesity hypertension metabolic syndrome depression anxiety obstructive sleep apnea nonalcoholic fatty liver disease endometrial cancer cardiovascular disease Research suggests that medication alone might not be enough to address PCOS

The methylation status of 15-LOX-1's promoter was not linked to its upregulation in OA cartilage, indicating that alternative mechanisms may be at play

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[Abstract] Mol Cancer