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These may represent aggregated peptide that cannot be restored to functional form, or they may indicate contamination

Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, et al

Manousou, S., Eggertsen, R., Hulthn, L

& Gandolfi, M

Importantly, RRM2 is often found overexpressed in NB, and its depletion was shown to induce G1/S phase arrest due to replicative stress and checkpoint kinase 1 (CHK1) activation (47, 48)