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iron-mediated programmed cell death that is characterized by oxidative cell death resulting from iron-dependent accumulation of lipid reactive species

doi: 10.1615/JEnvironPatholToxicolOncol.v28.i1 161 StejskalVDDanersundALindvallAHudecekRNordmanVYaqobAet al

Tan M, Yin Y, Ma X, Zhang J, Pan W, Tan M, et al

Obesity has the most severe consequences since it is associated with systemic inflammation, hypertension, and hypercholesterolemia, which represent conditions that increase the risk of developing cardiovascular disease and T2DM

Lancet Neurol 15(5):455532

Under normal physiological conditions, about 3% of cytosolic glucose is processed via the polyol pathway, however, at higher concentrations of glucose, about 30% of the glucose enters the polyol pathway which makes it important in disposing of the glucose molecules and subsequent conversion to sorbitol [128]