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The strategies to deal with these problems are discussed, aiming at the modification of nanocarriers, stimuli-sensitive systems, and immunomodulatory approaches

Apigenin-loaded galactose tailored PLGA nanoparticles: a possible strategy for liver targeting to treat hepatocellular carcinoma

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Current Limitation and Challenges Despite knowledge gained and discussed above and the tremendous clinical success in cancer therapy in the present era, the clinical application of genistein as a promising therapeutic agent for cancer treatment is not fully understood

In particular, these cells highly express the monocarboxylate transporter MCT4 on their plasma membrane, which transports intracellularly accumulated lactate into the microenvironment, accelerating glycolytic flux [41, 42]

doi: 10.3390/pharmaceutics11010022