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The BAC- SNCA A53T/ mice can be used as a model of prodromal PD because they develop characteristic non-motor symptoms, such as rapid eye movement (REM) sleep behavior disorder at 5 months old and hyposmia at 9 months old despite presenting a mild age-dependent DA neurodegeneration phenotype

Almost 90% of those with diabetes have type 2 DM, the most prevalent DM [79, 80] and causes chronically high blood glucose levels by reducing insulin secretion or activity

Nature 419 (6095), 384387 (2002)

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