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Collectively, major barriers to the clinical translation of NPPC-based therapies include difficulties in cell sourcing and characterization, in vitro expansion, post-transplantation survival and integration, the efficient recruitment of endogenous cells, and the identification of suitable patient populations

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Indeed, we found male L-DKO mice to have a greater hepatocellular injury than female Gclc L-KO mice (Fig

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In practical terms, aging mitochondria become better at converting fuel into usable energy, which is precisely the mechanism that declines with age

Ginsenoside 20(S)-Rg3 and ginsenoside Rb3 can inhibit autophagy to improve renal injury by blocking the JNK-P53-caspase-3 signaling cascade [101, 102]