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In fact, before the recognition of glutamate transport activities, VGLUT1 and VGLUT2 were originally cloned as plasma membrane Na + -dependent inorganic phosphate transporters, given that their heterologous expression stimulates Na + /Pi co-transport into Xenopus oocytes (Ni et al., + -dependent phosphate transport (Juge et al., + -dependent Pi transport into SVs, which competes with glutamate transport (Preobraschenski et al., + exchange in SVs, which would convert pH to , thereby facilitating the -driven glutamate transport (Preobraschenski et al., Despite accumulating in vitro evidence from mechanistic insights into glutamate transport modulation by various ions, the physiological relevance of the foregoing biochemical observations in living synapses is largely unexplored, mainly due to technical constraints in manipulating and quantitatively measuring glutamate and various ion concentrations in the cytoplasm and in vesicle lumens

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In addition, Nrf2 triggered AKR1C1 expression to attenuate iron toxicity-induced cell injury and inflammation in HCECs

For example, the variant 677T is most commonly associated with cerebral vascular accident (stroke), elevated homocysteine, cardiovascular disease risk, peripheral neuropathy, deep vein thrombosis, early-onset heart disease, stillbirth, neuro-tube defect, cleft lip, and preeclampsia

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Cobalamin deficiencies in adults: update of etiologies, clinical manifestations and treatment