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(1999), Philp et al

People with pernicious anemia or other medical conditions affecting B12 levels

Depression and Apathy: Psychiatric symptoms are very common and often appear early in the disease course

Apoptosis Apoptosis involves intricate intrinsic and extrinsic signaling pathways [90]

Inflammation and gut microbiota play crucial roles in both psychological distress and liver disease initiation and progression, while the sickness behavior theory explains that peripheral inflammation can lead to behaviors like fatigue, lethargy, impaired concentration, and social withdrawal