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91 (2), e20181257

Warden BA, Fazio S, Shapiro MD

Effect of concomitant use of pentoxifylline and alpha-tocopherol with radiotherapy on the clinical outcome of patients with stage IIIB non-small cell lung cancer: a randomized prospective clinical trial

In addition to data reduction/visualization methods such as Principle Component Analysis (PCA), Partial Least Squares Discriminant Analysis (PLS-DA) and Orthogonal Partial Least Squared Discriminant Analysis (OPLS-DA) (222, 249), any form of targeted or global metabolomic analysis requires befitting statistical analysis, for example with Multivariate Analysis of Variance (MANOVA) or related approaches (37) for determination of significant discriminating biomarkers