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For the uni, speed is another constraint, and I understand that you need shorter cranks to go fast, given a certain wheel-size

10.1038/s41380-021-01073-6 137

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Kurzawski M., Dziedziejko V., Urasiska E., Post M., Wjcicki M., Mitkiewski J., Drodzik M

This is important in ensuring that your skin is healthy and strong

My answer would be, if you can afford it, yes

Together with previous work showing that perturbations of the N-terminal loop or -SNAP/Sec17 membrane engagement compromise SNARE complex disassembly and membrane fusion dynamics 11,37,38 , these findings support the idea that the M105I mutation may impair membrane fusion not only by diminishing plasma membrane binding, but also by diverting -SNAP into non-productive, off-pathway membrane contacts that cannot support a properly assembled 20S complex