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While supportive evidence has been obtained from animal models and preliminary clinical studies, further large-scale, long-term randomized controlled trials are imperative to establish its safety and evaluate its clinical efficacy comprehensively

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Firstly, while the role of enhanced glycolysis in fibroblast activation is well-documented, the precise regulatory mechanisms governing this metabolic shift require further investigation

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4 Conclusion and perspectives Although human kidney diseases arise from complicated pathological mechanisms and different etiologies, mitochondrial dysfunction is no doubt plays an important role in the pathogenesis