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Throughout the kinase reactions, His-RbC (Rb aa: 772928) was used at low micromolar concentrations (0.52 M), while enzyme concentrations were maintained in the low nanomolar range

Nitric oxide (NO) is a small signaling molecule involved in how cells communicate, especially in contexts linked to vascular biology and cellular stress responses

The activation of SIRT1 by RES is closely linked to the adenosine monophosphate kinase (AMPK) pathway, where AMPK increases nicotinamide phosphoribosyltransferase (NAMPT) expression, raising intracellular NAD levels and further activating SIRT1 [36]

Zhang J, Bar-Peled L (2023) Chemical biology approaches to Uncovering nuclear ROS control

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