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34: 1496500 Moorthy AV, Rosenblum M, Rajaram R, et al

Yancy et al., 2017

Furthermore, GPX4 deficiency significantly decreased the number (Figure 1F), proliferation (Figure 1G), and IFN- production (Figure 1H) of CD8 + T cells, and diminished completely the capability of exogenous GSH to promote the expansion and function of CD8 + T cells

These and other data suggest that the web of interactions between these signaling components is indeed very complex (Figure 1)

Tumor cell progression and drug resistance have been reported to be associated with elevated cellular GSH levels, GCL activity, GCLC gene transcription and mRNA levels [48, 49]

These compounds interact with biological pathways related to fat breakdown, mitochondrial function, and metabolic signaling