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Key Words: end-stage liver disease, acute-on-chronic liver failure, chronic liver failure, acute decompensation of cirrhosis, infection 3207-A DISTINCT EFFECTS OF SENESCENCE CLEARANCE ON ALCOHOL-INDUCED LIVER INJURY IN YOUNG AND AGING INK-ATTAC MICE Tian Tian 1 , Chunbao Sun 2 , Sreenivasulu Basha 2 , Hua Wang 1 and Liya Pi 2 , (1)Anhui Medical University, (2)Tulane University School of Medicine, New Orleans, LA Background: Senescence is a state of permanent cell cycle arrest employed by cells due to replicative or stress-related mechanisms