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At the time of this review, there is essentially no high-level evidence demonstrating any benefit for oral therapy

This review is focused on the use of poly (lactic-co-glycolic acid) (PLGA)-based nanosystem as advanced drug delivery carriers for PD due to its versatility, safety, biodegradability, and extensive studies which evaluated the use of PLGA for drug delivery

Jolly RA, Cornwell PD, Noteboom J et al (2024) Estimation of acceptable daily intake values based on modeling and in vivo mutagenicity of NDSRIs of fluoxetine, duloxetine and atomoxetine

co-treatment with dexamethasone attenuated these effects and increased the expression of the antioxidant enzyme glutathione peroxidase 3 (GPX3), as revealed via RNA-sequencing

Ca 2+ subsequently enters the mitochondrial matrix through the mitochondrial calcium uniporter to cause mitochondrial swelling and membrane potential collapse, ultimately leading to cell death (Fig