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The primary mechanism of action involves the activation of telomerase, an enzyme responsible for maintaining and extending telomeresthe protective caps at the ends of chromosomes

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Bilirubin is a breakdown product of heme, that non-protein part of hemoglobin)

doi: 10.1016/j.anireprosci.2015.12.001 102 PuglisiRMaccariIPipoloSConradMMangiaFBoitaniC

For instance, an in vivo study in RA models used poly(lactic-co-glycolic acid)poly(ethylene glycol)-maleimide (PLGA-PEG-MAL) NPs conjugated with joint-relevant peptide antigens (aggrecan 70-84 and type II bovine collagen 256-270 ) and encapsulating calcitriol [152]