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Oil red O staining showed that lipid accumulation was observed in the kidneys of both diabetic mouse models and DKD patients, and was mainly located in the proximal tubules (24)

NNMT activity is elevated in adipose tissue and linked to reduced NAD+ availability, impaired mitochondrial function, and metabolic inflexibility

[DOI] [PubMed] [Google Scholar] 140.Linck V.M., Costa-Campos L., Pilz L.K., Garcia C.R., Elisabetsky E

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Extracellular Matrix Remodeling Assays: Utilized in studies focused on matrix structure, cellular adhesion, and signaling between cells and their surrounding environment

Redox Biol 28:101343 Warren RB, Mrowietz U, von Kiedrowski R, Niesmann J, Wilsmann-Theis D, Ghoreschi K, Zschocke I, Falk TM, Bldorn-Schlicht N, Reich K (2017) An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial