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Some of these CD38-specific hcAbs have been shown to inhibit the GDPR cyclase activity of CD38, while others induce mechanisms of cytotoxicity in mouse tumor models [91]

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Wang XM, Lemos JR, Dayanithi G, Nordmann JJ, Treistman SN

Adult dogs receiving the tablet formulation for 30 consecutive days at a daily treatment of 25 mg/kg did not exhibit significant clinical signs nor were there effects upon the clinical chemistry, hematological or histological parameters