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It does not simply suppress appetite or create a caloric deficit

Additionally, dysbiosis may compromise intestinal barrier integrity, resulting in microbial translocation, commonly referred to as leaky gut, where microbial components (e.g., LPS, fungal antigens) enter the bloodstream [40,43,68,69,70]

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Trials that fail to account for baseline selenium levels may underestimate the potential benefits of supplementation, as selenium-replete patients are unlikely to experience significant improvement