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After 1 year of treatment, the patients biological age was reduced by 7.9 years (from 75.93 to 68.03), and his telomere length increased from 6.45 to 6.59 kb (Table 3)

To date, there is still no effective treatment for ALS, and the two currently available drugs, riluzole and edaravone, only extend survival of ALS patients by few months [78,79,80,81,82,83]

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People with diabetes who take metformin are at higher risk of developing B12 deficiency because this drug can reduce the absorption of vitamin B12 in the body B12 deficiency impairs motor and sensory nerve function