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J Hum Hypertens 33 , 844855 (2019)

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In considering the use of Macrodantin, lower eradication rates should be balanced against the increased potential for systemic toxicity and for the development of antimicrobial resistance when agents with broader tissue distribution are utilized

stage 4 is graded as severe and assigned a score more than 40

Bot Res Int 2(4):218228 Khan M, Shah AJ, Gilani AH (2013) Antidiarrheal and antispasmodic activities of Vitex negundo are mediated through calcium channel blockade