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[4] highlighted that curcumin exhibits poor systemic bioavailability in humans, even at high oral doses up to 12 g/day, due to poor intestinal absorption, extensive metabolism, and rapid systemic elimination

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10.1016/j.biopha.2023.114222 94 LiX.YangX.LuH.WangW.CaiL.ChenJ.et al (2023b)

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Beyond direct immune signaling, BAs significantly influence systemic inflammation by modulating intestinal permeability

These issues often begin mildly and increase in severity: Constipation or diarrhea Acid reflux Skin disorders (eczema, acne) Altered taste Bloating and gas Weight gain or loss Always hungry Nausea Feeling tired after eating Food sensitivities Frequent belching Vomiting Undigested food in stools Poor appetite Geographic tongue and various tongue coatings Autoimmune conditions Joint discomfort Muscle aches Cognitive issues The 3 Phases of Digestion There are three main phases of digestion: The Cephalic Phase The Gastric Phase The Intestinal Phase The Cephalic Phase (known as the preparatory phase): Ever see your dog drooling as you prepare their food