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Co-treatment with 3-BP and cetuximab stabilizes FOXO3a by inhibiting FOXO3a phosphorylation We then investigated the effects of co-treatment on preventing FOXO3a degradation

10.3389/fphar.2018.00530 Front Pharmacol

Further studies, especially using human plasma exosomes from alcohol drinkers are required to explore the full potential of the plasma exosomal cargo, especially CYP2E1 and other CYP enzymes, as biochemical mediators in drug metabolism and resulting toxicity

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This will include targeted investment at priority sites as well as investigations and improvement work on parts of the sewer network to reduce infiltration