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It is hypothesized that 13-cis RA may hinder cell proliferation, promote cell death, alter gene and protein expressions, and diminish cell survival pathways in human meibomian gland epithelial cells

At the end of the experiments, the mice were sacrificed (cervical dislocation for short distribution time points and carbon dioxide asphyxia for longer ones), and the draining LNs (ipsilateral popliteal), the second LN in the chain (lumbar), and nondraining LNs (axillary and contralateral popliteal LNs) were rapidly dissected free (Figure 1A)

Plain sterile water lacks preservatives and is intended for single-use only after opening

Retinoids accelerate cell turnover and can cause severe skin irritation

& Walbeehm, E

J Biol Chem 281:1038910398