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On another hand, CFTR has been described as a broken transporter because it is an ion channel that has evolved from an ABC transporter

Biol Trace Elem Res 199(11):40744083

Fu L, Xu BT, Xu XR, Gan RY, Zhang Y, Xia EQ , et al

J Nutr (2006) 136:1652S9S

This synergy between transcription factors reinforces cellular redox balance, counteracts oxidative DNA damage, and inhibits melanoma cell proliferation 160

Constipation affects 11-24% of patients taking these medications, typically developing within the first 4-8 weeks of treatment as the digestive system adjusts to slower motility