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The patient receives injection training, a written protocol with timing and dosing instructions, and a follow-up schedule

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Interleukin-1 (IL-1) and tumor necrosis factor- (TNF) are two important inflammatory cytokines that not only lead to cartilage matrix destruction, but also prevent chondrogenic differentiation of mesenchymal stem cells

Elsevier, Oxford, pp 16301633 Tuchman M, Lee B, Lichter-Konecki U, Summar ML, Yudkoff M, Cederbaum SD, Kerr DS, Diaz GA, Seashore MR, Lee HS, McCarter RJ, Krischer JP, Batshaw ML (2008) Cross-sectional multicenter study of patients with urea cycle disorders in the United States